round button
Categories
How To Order | Shipping Policy | FAQ | Contact Us

Customer Support: +18102015692
Refer Friend

Sildenafil Tablets
♂ Viagra Red

  • Viagra Tablets
  • BRD008
  • In Stock

Premium High Quality Product & Original Active Substance!

Select Doses:

   Manufacturer's Suggested Retail Price (MSRP) per pill is $5.07 ! Buying from us will save you at least 49.51%

Package per pill Price SAVINGS BONUS Order
100mg * 30 pills
$2.56 $76.80 $0.00
+ SILVER BONUS
SILVER BONUS
for orders under $300
►Package delivery insurance
►Next orders 10% discount
100mg * 60 pills
$2.31 $138.60 $15.00
+ SILVER BONUS
SILVER BONUS
for orders under $300
►Package delivery insurance
►Next orders 10% discount
100mg * 90 pills
$2.29 $206.10 $24.30
+ SILVER BONUS
SILVER BONUS
for orders under $300
►Package delivery insurance
►Next orders 10% discount
100mg * 120 pills
$1.91 $229.20 $78.00
+ SILVER BONUS
SILVER BONUS
for orders under $300
►Package delivery insurance
►Next orders 10% discount
100mg * 150 pills
$1.73 $259.50 $124.50
+ SILVER BONUS
SILVER BONUS
for orders under $300
►Package delivery insurance
►Next orders 10% discount
100mg * 180 pills
$1.59 $286.20 $174.60
+ SILVER BONUS
SILVER BONUS
for orders under $300
►Package delivery insurance
►Next orders 10% discount

Sildenafil is a vasoactive agent used to treat erectile dysfunction and reduce symptoms in patients with pulmonary arterial hypertension (PAH). Sildenafil elevates levels of the second messenger, cGMP, by inhibiting its breakdown via phosphodiesterase type 5 (PDE5). PDE5 is found in particularly high concentrations in the corpus cavernosum, erectile tissue of the penis. It is also found in the retina and vascular endothelium. Increased cGMP results in vasodilation which facilitates generation and maintenance of an erection. The vasodilatory effects of sildenafil also help reduce symptoms of PAH.

For the treatment of erectile dysfunction and to relieve symptoms of pulmonary arterial hypertension (PAH).

Red Viagra is indicated for the treatment of erectile dysfunction in men. This medication has a more enhanced formula (compared to standard Viagra) which helps to achieve the desired effect faster.

Erections are controlled by the parasympathetic nervous system. Upon sexual stimulation, a decrease in vascular resistance is mediated by acetylcholine and nitric oxide resulting in vasodilation. The hemodynamic mechanism of an erection is comprised of five stages. During the latent stage, arterial and carvernous smooth muscle relaxation occurs. Vasodilation results in high levels of blood flow causing the penis to grow to its full size. This stage is called tumescence.

During the full-erection stage, blood flow fills penis sinusoids and outflow is restricted. This is followed by the rigid-erection phase during which the cavernous muscles contract causing the penis to become rigid. Little blood flow occurs during this stage. During the final stage, detumescence, the cavernous muscles relax and blood flows out of the penis. Erectile dysfunction may occur when there is insufficient blood supply to the penis or when the penis is unable to prevent outflow of blood from the penis.

Sildenafil is a specific inhibitor of PDE5, an enzyme responsible for the breakdown of cGMP to 5’-GMP. Increased levels of cGMP stimulate vasodilation and facilitate the generation and maintenance of erections. These vasodilatory effects also help decrease symptoms of PAH. Sildenfail also exhibits some activity against PDE6 (10 times less potentcy compared to PDE5), a PDE isoform found predmoninantly in the retina. This activity is responsible for the blue tinged vision experienced by users of sildenafil.

Sildenafil inhibits the cGMP-specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum located around the penis. Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle.

This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) by sildenafil enhances erectile function by increasing the amount of cGMP.

Metabolism: Sildenafil appears to be completely metabolized in the liver to 16 metabolites. Its metabolism is mediated mainly by cytochrome P450 microsomal isozymes 3A4 (major route) and 2C9 (minor route). The major circulating metabolite, N-demethylated metabolite, has PDE selectivity similar to the parent drug and ~50% of its in vitro potency. The N-demethylated metabolite is further metabolized to an N-dealkylated N,N-de-ethylated metabolite. Sildenafil also undergoes N-dealkylation followed by N-demethylation of the piperazine ring.

Absorption: >90% absorbed with ~40% reaching systemic circulation unchanged following first-pass metabolism

Route of elimination: Sildenafil is cleared predominantly by the CYP3A (major route) and cytochrome P450 2C9 (CYP2C9, minor route) hepatic microsomal isoenzymes. After either oral or intravenous administration, sildenafil is excreted as metabolites predominantly in the feces (approximately 80% of the administered oral dose) and to a lesser extent in the urine (approximately 13% of the administered oral dose).

Half life: 4 hours

All medicines may cause side effects, but many people have no, or minor, side effects.Some medical conditions may interact with Sildenafil.

Tell your doctor or pharmacist if you have any medical conditions.

Common sildenafil side effects may include: flushing (warmth, redness, or tingly feeling), headache, dizziness, abnormal vision (blurred vision, changes in color vision), runny or stuffy nose, nosebleeds, sleep problems (insomnia), muscle pain, back pain or upset stomach.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Jim
26/Jul/2024

Started working within 3 hours for me, and lasted for up to 12-16 hours; gives me really strong erection (100%). I prefer Viagra RED to Cialis because for me Cialis is slow to work (3-6 hours) and the quality of erection is poorer (max 80%).

Dewey
21/Jul/2024

I am 41 and found that I was not consistently staying hard after prolonged sex or masturbating. My recovery time after orgasm seemed like days...I am not on any other medication, very active person, and eat very healthy. I also do not smoke or drink alcohol...I decided to bring it up and look for a solution. Tried the Viagra Red 200mg and i was pleasantly surprised! I did get a flush feeling that went away. Also, I might get a slight headache the next morning but can be cleared up by taking something. However, the benefits were solid erections when turned on. It also lasts, like others mentioned, into the next day but not as strong. Again, you must be turned on for this to work. If you are not attracted, in the mood then it may not work well.

Bob
02/Jan/2024

Now, after 3 orders I can confidently say you do an awesome job. My friends also agree that you operate one of the best pharmacies online.

Finch
01/Jan/2024

I tried Viagra Red 200 mg last night for the first time and was surprised by how effectively it worked. I am 56 and achieved the strongest erection I have had in years. Now I am experiencing the headache and eyestrain described, but having sex like a teenager was worth it.

Write a review

Note: HTML is not translated!
    Bad 
 
 
 
 
 Good
TOP
a